Analysis performed on 2024-09-30 10:19:57
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 19361 | 256 | 19105 | 12053 |
| Vertebrata | 1443 | 273 | 1170 | 474 |
| Archaea | 1395 | 60 | 1335 | 408 |
| Mammals | 557 | 94 | 463 | 129 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 548 | 15 | 476 |
| Domains | |
|---|---|
| Current Study | 1, 111 |
| Guo et al (2010) | 1, 99 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 438 | 110 | 548 | 3.981818 |
| Number of Variants | 413 | 78 | 491 | 5.294872 |
| Number of Pathogenic Variants | 12 | 3 | 15 | 4.000000 |
| Number of Benign/Unknown Variants | 401 | 75 | 476 | 5.346667 |
| Fisher exact test | 0.716963 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 449 | 99 | 548 | 4.535354 |
| Number of Variants | 423 | 68 | 491 | 6.220588 |
| Number of Pathogenic Variants | 12 | 3 | 15 | 4.000000 |
| Number of Benign/Unknown Variants | 411 | 65 | 476 | 6.323077 |
| Fisher exact test | 0.448292 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 438 | 110 | 0.90 (0.01) | 0.88 (0.01) | 9.327e-01 | 9.389e-01 | 25551.50 | 1.62e-01 |
| Guo et al (2010) | 449 | 99 | 0.90 (0.01) | 0.88 (0.01) | 9.325e-01 | 9.433e-01 | 23050.50 | 2.82e-01 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.